RAF Typhoon fighter aircraft have joined forces with France's air force in a coordinated attack against an subterranean weapons facility in Syrian territory used by the Daesh militant organization, according to the UK's MoD.
The location, located using reconnaissance, was assessed as storing arms and explosives, the statement said, and was positioned in hills just to the north of Palmyra in Syria's central region.
"Our aircraft employed Paveway IV guided bombs to strike a several approach shafts leading to the site... early reports suggest the objective was successfully hit," the MoD said.
There was no evidence of any civilian impact in the operation on Saturday evening and every plane involved returned to base without incident, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
The Islamic State group - also known as Daesh - enforced jihadist rule over large swathes of both Syria and Iraq until 2019.
"This strike demonstrates British leadership, and commitment to operate in unison with our allies, to stamp out any resurgence of the terrorist group and their violent and radical beliefs in the region," the British Defence Secretary John Healey said.
British military aircraft have conducted patrols over Syrian airspace to "prevent any attempted comeback" of IS following its military defeat at the battle of Baghuz in the year 2019, the ministry said.
"I must thank all the members of British forces involved in this mission for their skill and their valour," he commented. "They were part of a great many UK service members on duty over Christmas and New Year. This operation, to take out terrorist threats who threaten our way of life, highlights how our armed forces are prepared to act, continuously, ensuring Britain's security at home and influential overseas."
In December, the American forces conducted what it described as a "large-scale strike" on Islamic State objectives in the country, after an assault resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The U.N. says Islamic State still boasts an estimated 5,000 to 7,000 combatants in Iraq and Syria.