Fresh analysis reveals that individuals who come off blockbuster GLP-1 drugs like Wegovy and Mounjaro tend to recover shed pounds far faster than those who halt conventional lifestyle regimens.
Research printed in a prominent health publication shows that while obese people often shed a large proportion of their body weight while using the jabs, the weight is regained at an average rate of 0.8 kg per month once they quit.
"People using these treatments must be aware of the risk of rapid rebound weight gain when the treatment concludes," warns expert Dr. Susan Jebb.
This pace of regain implies a reversion to starting mass within about a year and a half.
Comparing Treatments
The research, which examined 37 of studies involving over 9,000 of participants, compared the results of the injectable medications with conventional dieting.
The team note that people who shed pounds through diet and exercise typically have a less rapid creep back—approximately 100 grams monthly—after stopping.
Explaining the Quick Rebound
Experts propose the mechanism of the jabs explains the accelerated regain.
GLP-1 drugs imitate a natural hormone called GLP-1, which moderates feelings of fullness.
"Sustained high doses of the hormone levels far above than normal could lead to the body to generate a reduced amount of its own natural GLP-1, and may also reduce sensitivity to its effects," explained Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication leads to hunger is uncontrolled, making binge eating far more likely."
A Chronic Issue?
Medical guidelines recommend the injections for individuals with obesity-related medical conditions, alongside recommended diet and exercise modifications.
Professionals argue that, given the significant potential of weight regain, the therapy might need to be ongoing.
This view is reinforced by drug manufacturers, who say that the results "underscore the persistent nature of excess weight," comparing it to managing diseases like hypertension.
Patient Accounts
Individuals who have discontinued the jabs report a sudden resurgence of appetite.
"It felt as if a switch that goes on and you become ravenous," recalled an individual.
This difficulty is compounded if individuals have not adopted permanent lifestyle or habit modifications during therapy.
Growing Adoption
Figures indicate that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with demand being substantial.
- Use is greater among females than males.
- The 40s and 50s demographic shows the highest usage rates.
- Many access the drugs through private prescriptions rather than the NHS.
Finally, experts caution that while these medications are effective agents for shedding pounds, they are not a permanent solution and lasting health benefits hinges on integrated behavioural changes.
